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Watch Intently (one)phenobarbital will minimize the extent or influence of fentanyl transmucosal by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep track of Intently. Coadministration of fentanyl with CYP3A4 inducers may lead to a reduce in fentanyl plasma concentrations, insufficient efficacy or, probably, improvement